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Table 1 Potential protein kinase A substrates involved in the regulation of human uterine relaxation

From: Cyclic AMP signalling pathways in the regulation of uterine relaxation

Physiological roles (see Shabb (2001) [38])

Protein substrate (HUGO nomenclature)

References

Autophosphorylation

cAMP dependant protein kinase regulatory subunit type IIα (PRKAR2A)

Zakhary et al. (2000) [39]

cAMP signalling

β-2 adrenoceptor (ADRB2)

Daaka Y et al. (1997) [40]; Iyer et al. (2006) [41]

 

G protein coupled receptor kinase-2 (ADRBK1)

Houslay & Baillie (2006) [42]

 

Phosphodiesterase 4 (PDE4)

Murthy et al. (2002) [43]

Phosphoinositide and calcium signalling

InsP3 Type I receptor (ITPR1)

Straub et al. (2004) [44]

 

Phospholipase-C β3 (PLCB3)

Yue et al. (1998) [45]

 

Phospholipase-C γ1 (PLCG1)

Park et al. (1992) [46]

 

ATPase 2 (ATP2)

Tribe et al. (2000) [47]

 

Regulators of G-protein signalling (RGS)

Suarez et al. (2003) [48]

 

Thromboxane A2 receptor (TBXA1R)

Walsh et al. (2000) [49]

Rho signalling

RhoA small GTP binding protein (RHOA)

Murthy et al. (2003) [50]

 

Gα13

Manganello et al. (2003) [51]

Smooth muscle contraction

Myosin light chain kinase (MYLK)

Hirano et al. (2004) [52]

 

Myosin binding subunit of myosin phosphatase (PPP1R12A)

Wooldridge et al. (2004) [53]