Table 1 Summary measures of psychotropic prescription drug use before, during and after pregnancy
N = 343299 | 6 months preconcept n (%) | 1st trimester n (%) | 2nd trimester n (%) | 3rd trimester n (%) | Pregnancy total n (%) | Pregnancy total with >1 Rx n (%) |
|---|---|---|---|---|---|---|
Any psychotropic | 33,995 (9.9) | 24776 (7.2) | 15883 (4.6) | 18161 (5.3) | 35303 (10.3) | 23261 (6.8) |
Antidepressant | 23,083 (6.7) | 17214 (5.0) | 12235 (3.6) | 11937 (3.5) | 22275 (6.5) | 15097 (4.4) |
 SSRI | 16524 (4.8) | 12881 (3.8) | 9773 (2.9) | 9751 (2.8) | 17410 (5.1) | 12278 (3.6) |
 SNRI | 3170 (0.9) | 2175 (0.6) | 973 (0.3) | 805 (0.2) | 2382 (0.8) | 1075 (0.3) |
 Tricyclic | 1222 (0.4) | 611 (0.2) | 236 (0.07) | 209 (0.06) | 784 (0.2) | 308 (0.1) |
 Other | 4390 (1.3) | 3085 (0.9) | 1875 (0.6) | 1634 (0.5) | 4019 (1.2) | 1026 (0.3) |
 ≥ 2 antidepressants | 2776 (0.8) | 2132 (0.6) | 889 (0.3) | 676 (0.2) | 3521 (1.0) | 1613 (0.5) |
Anxiolytic | 12969 (3.8) | 7503 (2.2) | 3881 (1.1) | 7002 (2.0) | 14535 (4.2) | 9235 (2.7) |
 Benzo or benzo-like* | 12231 (3.5) | 6840 (2.0) | 3391 (1.0) | 6686 (2.0) | 13486 (3.9) | 8613 (2.5) |
 Other | 950 (0.3) | 809 (0.2) | 549 (0.2) | 377 (0.1) | 1375 (0.4) | 757 (0.2) |
Antipsychotic | 1344 (0.4) | 1728 (0.5) | 808 (0.2) | 503 (0.1) | 2373 (1.1) | 1015 (0.3) |
 Atypical | 899 (0.3) | 604 (0.2) | 315 (0.1) | 301 (0.1) | 742 (0.2) | 388 (0.1) |
 Typical | 357 (0.1) | 1072 (0.3) | 464 (0.1) | 160 (0.05) | 1573 (0.5) | 995 (0.3) |
Stimulant/ADHD | 2798 (0.8) | 1982 (0.6) | 498 (0.1) | 325 (0.1) | 2062 (0.6) | 545 (0.2) |
 ≥ 2 categories of psychotropic** | 5423 (1.6) | 3339 (1.0) | 1431 (0.4) | 1519 (0.5) | 5423 (1.6) | 2390 (0.7) |
 Antidepressant + anxiolytic | 4195 (1.2) | 2293 (0.7) | 1064 (0.3) | 1247 (0.36) | 4068 (1.2) | 1630 (0.5) |