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Table 1 Detection of Trisomy 21 with fixed false positive rates

From: The utility of circulating LHCGR as a predictor of Down's syndrome in early pregnancy

Markers AUCDF 5% FPR 10%FPR
βhCG + PAPPA 0.918 0.49(0.27 – 0.73) 0.73(0.55 – 0.92)
PAPPA + NT 0.922 0.66(0.5 – 0.81) 0.78(0.64 – 0.9)
PAPPA + hCG-sLHCGR 0.92 0.81(0.68 – 0.91) 0.84(0.74 – 0.95)
βhCG + hCG-sLHCGR 0.856 0.53(0.39 – 0.75) 0.65(0.5 – 0.83)
βhCG + NT 0.753 0.23(0.11 – 0.37) 0.36(0.23 – 0.51)
hCG-sLHCGR + NT 0.888 0.71(0.56 – 0.84) 0.77(0.63 – 0.88)
NT + PAPPA + βhCG 0.94 0.59(0.35 – 0.83) 0.83(0.66 – 0.97)
NT + PAPPA + hCG-sLHCGR 0.928 0.84(0.72 – 0.95) 0.87(0.76 – 0.98)
hCG-sLHCGR + NT + PAPPA + βhCG 0.966 0.83(0.73 – 0.92) 0.9(0.82 – 0.97)