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Table 4 Risk of adverse pregnancy outcomes with 95% confidence intervals according to hyperemesis gravidarum (N = 71,468)

From: Hyperemesis gravidarum and pregnancy outcomes in the Norwegian mother and child cohort – a cohort study

 

n (%)

Prevalence (%) (95% CI)

Crude odds ratio (95% CI)

Adjusted odds ratio (95% CI)*

Adjusted odds ratio (95% CI)***

Adjusted odds ratio (95% CI)****

Gestational age < 37 weeks

3157 (4.4)

     

 No hyperemesis (HG)

 

4.4 (4.3- 4.6)

1 Reference

1 Reference

1 Reference

1 Reference

 HG

 

5.3 (5.1- 5.4)

1.21 (0.89-1.65)

1.18 (0.86-1.60)

1.15 (0.84-1.57)

1.02 (0.75-1.40)

Birthweight < 2500 grams

1791 (2.5)

     

 No HG

 

2.5 (2.4- 2.6)

1 Reference

1 Reference

1 Reference

1 Reference

 HG

 

2.5 (2.3- 2.6)

0.98 (0.63-1.53)

0.80 (0.47-1.36)**

0.80 (0.47-1.35)**

0.72 (0.42-1.24)**

Small for gestational age

6793 (9.5)

     

 No HG

 

9.5 (9.3- 9.7)

1 Reference

1 Reference

1 Reference

1 Reference

 HG

 

9.6 (9.4- 9.8)

1.01 (0.80-1.28)

1.10 (0.87-1.40)

1.11 (0.87-1.40)

1.01 (0.80-1.29)

Apgar score after 1 minute < 7

3553 (5.0)

     

 No HG

 

5.0 (4.8-5.2)

1 Reference

1 Reference

1 Reference

1 Reference

 HG

 

3.2 (3.1-3.3)

0.63 (0.42-0.93)

0.62 (0.42-0.93)**

0.62 (0.42-0.93)**

0.64 (0.43-0.95)**

Apgar score after 5 minutes < 7

848 (1.2)

     

 No HG

 

1.2 (1.1-1.3)

1 Reference

1 Reference

1 Reference

1 Reference

 HG

 

1.2 (1.1- 1.3)

1.04 (0.55-1.94)

1.07 (0.56-2.02)**

1.04 (0.55-1.97)**

1.11 (0.58-2.12)**

Perinatal death

167 (0.2)

     

 No HG

 

0.2 (0.2- 0.3)

---

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---

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 HG

 

0.0 (−−)

    
  1. *Adjusted for maternal age, parity, BMI, education and smoking habits.
  2. **Additional adjustment for gestational age and induction.
  3. ***Additional adjustment for asthma, diabetes 1, thyroid disease, depression, anxiety, other psychological problems, anorexia, anemia and vitamin B12 deficiency.
  4. ****Adjustment for maternal weight gain during pregnancy.